Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats

Table 12

Effect of GutGard on relative organ weights (%) of female rats during 90 D oral toxicity study.

Parameter	Dose (mg/kg)
	0	0 (Rev)^$	250	500	1000	1000 (Rev)^$
Brain	0.723 ± 0.077	0.711 ± 0.056	0.774 ± 0.057	0.802 ± 0.051	0.780 ± 0.074	0.728 ± 0.080
Liver	2.812 ± 0.324	3.013 ± 0.254	2.904 ± 0.260	3.261 ± 0.372	3.718 ± 0.539	2.891 ± 0.405
Kidneys	0.670 ± 0.070	0.649 ± 0.058	0.669 ± 0.048	0.750 ± 0.044	0.750 ± 0.028	0.623 ± 0.076
Adrenals	0.0263 ± 0.0069	0.0234 ± 0.0083	0.0239 ± 0.0040	0.0289 ± 0.0041	0.0266 ± 0.0054	0.0236 ± 0.0041
Ovaries	0.0344 ± 0.0110	0.0467 ± 0.0082	0.0330 ± 0.0065	0.0429 ± 0.0082	0.0385 ± 0.0092	0.0395 ± 0.0078
Heart	0.323 ± 0.034	0.385 ± 0.026	0.360 ± 0.033	0.364 ± 0.039	0.360 ± 0.020	0.328 ± 0.065
Spleen	0.353 ± 0.062	0.371 ± 0.061	0.325 ± 0.073	0.385 ± 0.075	0.387 ± 0.079	0.299 ± 0.029
Thymus	0.060 ± 0.017	0.072 ± 0.019	0.071 ± 0.015	0.082 ± 0.025	0.060 ± 0.022	0.059 ± 0.025
Uterus	0.146 ± 0.058	0.186 ± 0.40	0.157 ± 0.033	0.163 ± 0.49	0.141 ± 0.018	0.184 ± 0.051

Mean ± SD (n = 10); ^$n = 5; Rev.: reversal.  = significant at 95% level of confidence ;  = significant at 99% level of confidence .