Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats

Table 2

Effect of GutGard on body weight of animals during 14D repeated toxicity study.

Group	Dose (mg/kg)	Day
		0	1	4	8	11	14	15
(a) Effect of GutGard on body weight of male rats during 14-day repeated toxicity study
I	0	141.06 ± 9.73	147.04 ± 10.81	166.22 ± 10.91	191.08 ± 19.18	209.50 ± 21.81	220.80 ± 25.64	203.38 ± 24.41
II	250	139.72 ± 10.43	144.96 ± 10.50	164.60 ± 8.05	184.74 ± 10.03	200.72 ± 11.15	206.54 ± 11.48	187.62 ± 13.90
III	500	139.68 ± 9.75	144.22 ± 9.38	161.42 ± 15.13	179.60 ± 27.18	195.90 ± 33.38	205.64 ± 31.65	186.10 ± 29.17
IV	1000	140.94 ± 7.76	144.88 ± 9.57	160.76 ± 12.13	178.86 ± 20.02	192.86 ± 26.75	205.46 ± 29.93	187.28 ± 27.66
(b) Effect of GutGard on body weight of female rats during 14-day repeated toxicity study
I	0	130.18 ± 5.12	133.68 ± 5.98	142.64 ± 9.57	157.08 ± 11.47	167.46 ± 14.70	173.44 ± 16.94	156.24 ± 13.86
II	250	130.14 ± 5.17	134.10 ± 4.38	145.42 ± 6.04	159.28 ± 9.44	167.84 ± 12.13	172.66 ± 11.14	157.78 ± 8.89
III	500	130.52 ± 4.70	134.56 ± 5.74	141.28 ± 9.09	150.52 ± 12.44	157.60 ± 12.05	163.42 ± 12.36	148.94 ± 11.23
IV	1000	130.96 ± 4.35	134.18 ± 6.00	140.24 ± 6.72	153.30 ± 7.74	162.64 ± 8.17	166.34 ± 7.60	151.02 ± 6.28

Mean ± SD (n = 5).