Research Article
Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats
Table 7
Effect of GutGard on urine parameters of male rats during 90 D oral toxicity study.
| | Parameter | Dose (mg/kg) | | 0 | 0 (Rev)$ | 250 | 500 | 1000 | 1000 (Rev)$ |
| | Volume (ml) | 4.81 ± 0.76 | 5.10 ± 0.20 | 5.07 ± 0.74 | 5.23 ± 0.47 | 5.00 ± 0.58 | 5.20 ± 0.45 | | Glucose (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | | Bilirubin (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | | Ketones (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | | Sp.Gr.(g/L) | 1.028 ± 0.003 | 1.027 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 | | OB (ca CELL/μL) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | | pH | 6.20 ± 0.26 | 6.30 ± 0.27 | 6.25 ± 0.26 | 6.25 ± 0.26 | 6.25 ± 0.26 | 6.20 ± 0.27 | | URB (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | | Nitrite | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
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Mean ± SD (n = 10); $ n = 5. Rev.: reversal; OB: occult blood; URB: urobilinogen; Sp.Gr.: specific gravity.
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