Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of Glycyrrhiza glabra (GutGard®) in Sprague Dawley Rats

Table 9

Effect of GutGard on absolute organ weights (g) of male rats during 90 D oral toxicity study.

Parameter	Dose (mg/kg)
	0	0 (Rev)^$	250	500	1000	1000 (Rev)^$
TBD (g)	372.56 ± 34.42	410.04 ± 25.95	359.73 ± 32.26	360.31 ± 32.48	350.15 ± 36.39	378.96 ± 14.02
Brain	1.943 ± 0.096	2.000 ± 0.137	1.943 ± 0.077	1.954 ± 0.080	1.949 ± 0.098	2.007 ± 0.109
Liver	11.258 ± 2.396	12.670 ± 2.026	10.931 ± 1.120	12.682 ± 2.422	13.189 ± 1.925	11.424 ± 0.824
Kidneys	2.622 ± 0.360	3.014 ± 0.304	2.596 ± 0.179	2.705 ± 0.358	2.889 ± 0.295	2.644 ± 0.219
Adrenals	0.0486 ± 0.0071	0.0472 ± 0.0061	0.0565 ± 0.0126	0.0533 ± 0.0052	0.0533 ± 0.0074	0.0432 ± 0.0071
Testes	2.851 ± 0.413	3.032 ± 0.082	2.937 ± 0.157	2.938 ± 0.290	2.860 ± 0.228	2.859 ± 0.192
Heart	1.197 ± 0.174	1.387 ± 0.184	1.178 ± 0.101	1.237 ± 0.212	1.166 ± 0.140	1.339 ± 0.155
Spleen	1.379 ± 0.482	1.148 ± 0.224	1.049 ± 0.261	1.308 ± 0.289	1.379 ± 0.174	0.956 ± 0.115
Thymus	0.210 ± 0.068	0.175 ± 0.059	0.160 ± 0.060	0.200 ± 0.053	0.147 ± 0.040	0.147 ± 0.022
Epididymis	1.182 ± 0.086	1.201 ± 0.151	1.068 ± 0.081	1.099 ± 0.134	1.130 ± 0.088	1.074 ± 0.061

Mean ± SD (n = 10); ^$n = 5; Rev.: reversal; TBD: total body weight.