Research Article
Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 11
Effect of body weight (g) of female animals during gestation and lactation period in reproductive/developmental toxicity study of AC3®.
| Treatment groups | Gestation period (days) | Lactation period (days) | 0 | 7 | 14 | 20 | 0 | 4 | 13 |
| Vehicle control | 244.07 ± 12.19 | 250.06 ± 12.32 | 272.82 ± 15.08 | 299.06 ± 22.90 | 221.78 ± 22.09 | 227.05 ± 21.84 | 243.97 ± 23.63 | Low dose-125 mg/kg b.w | 237.42 ± 9.76 | 243.84 ± 9.66 | 268.59 ± 7.59 | 302.36 ± 17.92 | 225.83 ± 17.45 | 232.56 ± 18.99 | 254.52 ± 16.73 | Mid dose-250 mg/kg b.w | 241.84 ± 10.94 | 252.63 ± 11.23 | 265.36 ± 10.77 | 295.95 ± 10.76 | 227.99 ± 14.15 | 235.28 ± 15.25 | 246.58 ± 14.18 | High dose-500 mg/kg b.w | 235.73 ± 9.77 | 246.09 ± 10.88 | 270.77 ± 17.64 | 300.61 ± 21.30 | 221.60 ± 15.49 | 230.61 ± 18.97 | 250.82 ± 18.18 |
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Values are expressed as mean ± SD. n = 10 for vehicle control, low, and high dose; n = 9 for mid dose.
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