Research Article
Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 7
Effect of 28 days exposure to AC3® on absolute organ weights (g) in Wistar rats.
| Organs | Sex | Vehicle control | Treated | Control recovery | High dose-500 mg/kg b.w recovery | Low dose-125 mg/kg b.w | Mid dose-250 mg/kg b.w | High dose-500 mg/kg b.w |
| Adrenals | M | 0.061 ± 0.015 | 0.069 ± 0.014 | 0.069 ± 0.008 | 0.074 ± 0.010 | 0.055 ± 0.014 | 0.045 ± 0.007 | F | 0.074 ± 0.018 | 0.069 ± 0.020 | 0.083 ± 0.022 | 0.056 ± 0.011 | 193.69 ± 9.60 | 200.47 ± 28.37 |
| Liver | M | 8.716 ± 1.269 | 8.904 ± 1.523 | 8.907 ± 1.657 | 8.875 ± 1.499 | 8.250 ± 0.954 | 8.318 ± 1.010 | F | 6.114 ± 0.690 | 6.481 ± 0.749 | 6.773 ± 0.197 | 6.315 ± 0.638 | 0.504 ± 0.222 | 0.423 ± 0.044 |
| Kidneys | M | 1.773 ± 0.173 | 1.818 ± 0.422 | 1.705 ± 0.283 | 1.632 ± 0.341 | 1.646 ± 0.175 | 1.737 ± 0.067 | F | 1.214 ± 0.133 | 1.287 ± 0.194 | 1.313 ± 0.169 | 1.242 ± 0.176 | 5.63 ± 0.77 | 6.11 ± 0.87 |
| Heart | M | 0.878 ± 0.018 | 0.878 ± 0.175 | 1.022 ± 0.197 | 0.896 ± 0.259 | 0.846 ± 0.060 | 0.977 ± 0.124 | F | 0.610 ± 0.094 | 0.750 ± 0.126 | 0.734 ± 0.114 | 0.676 ± 0.145 | 1.175 ± 0.135 | 1.211 ± 0.151 |
| Brain | M | 1.859 ± 0.062 | 1.849 ± 0.144 | 1.720 ± 0.090 | 1.732 ± 0.163 | 1.726 ± 0.076 | 1.791 ± 0.118 | F | 1.715 ± 0.053 | 1.688 ± 0.138 | 1.744 ± 0.083 | 1.705 ± 0.124 | 0.70 ± 0.11 | 0.67 ± 0.10 |
| Spleen | M | 0.711 ± 0.174 | 0.741 ± 0.104 | 0.894 ± 0.299 | 0.673 ± 0.146 | 0.748 ± 0.383 | 0.723 ± 0.185 | F | 0.620 ± 0.127 | 0.582 ± 0.190 | 0.626 ± 0.154 | 0.490 ± 0.134 | 1.702 ± 0.068 | 1.732 ± 0.055 |
| Thymus | M | 0.366 ± 0.081 | 0.305 ± 0.120 | 0.347 ± 0.078 | 0.390 ± 0.113 | 0.370 ± 0.094 | 0.319 ± 0.047 | F | 0.267 ± 0.051 | 0.364 ± 0.058 | 0.375 ± 0.100 | 0.309 ± 0.040 | 0.56 ± 0.12 | 0.50 ± 0.10 |
| Ovaries | F | 0.117 ± 0.007 | 0.122 ± 0.023 | 0.133 ± 0.012 | 0.140 ± 0.012 | 0.062 ± 0.024 | 0.060 ± 0.014 |
| Uterus with cervix | F | 0.558 ± 0.185 | 0.499 ± 0.023 | 0.133 ± 0.012 | 0.140 ± 0.012 | 0.10 ± 0.05 | 0.12 ± 0.04 |
| Prostate | M | 0.488 ± 0.133 | 0.500 ± 0.070 | 0.538 ± 0.192 | 0.465 ± 0.091 | 0.549 ± 0.132 | 0.490 ± 0.161 |
| Seminal vesicle with coagulation gland | M | 0.536 ± 0.170 | 0.584 ± 0.144 | 0.639 ± 0.255 | 0.489 ± 0.184 | 0.667 ± 0.194 | 0.650 ± 0.149 |
| Testes | M | 3.167 ± 0.201 | 3.046 ± 0.264 | 3.107 ± 0.227 | 2.775 ± 0.524 | 2.984 ± 0.203 | 3.034 ± 0.269 |
| Epididymis | M | 1.026 ± 0.051 | 1.135 ± 0.093 | 1.124 ± 0.144 | 0.900 ± 0.239 | 1.063 ± 0.117 | 0.987 ± 0.168 |
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Values are expressed as mean ± SD, n = 5. M: male; F: female.
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