Research Article
Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.
Table 1
The body weight and relative organ weights of mice treated orally with CECPM for 14 days.
| Parameters | Groups | Control | CECPM (313 mg/kg·bw) | CECPM (625 mg/kg·bw) | CECPM (1250 mg/kg·bw) | CECPM (2500 mg/kg·bw) | CECPM (5000 mg/kg·bw) |
| Body weight | Initial weight (g) | 36.68 ± 2.47 | 33.08 ± 3.51 | 36.04 ± 3.05 | 35.82 ± 3.72 | 36.24 ± 1.40 | 34.52 ± 2.89 | Final weight (g) | 38.90 ± 2.28 | 36.36 ± 3.17 | 38.76 ± 6.05 | 38.82 ± 4.01 | 39.80 ± 1.07 | 37.88 ± 2.61 | Body weight gain (g) | 2.22 ± 0.40 | 3.28 ± 4.46 | 2.72 ± 3.89 | 3.00 ± 1.49 | 3.56 ± 0.59 | 3.32 ± 1.16 | Organ weight | Kidney (g) | 0.42 ± 0.03 | 0.43 ± 0.04 | 0.40 ± 0.04 | 0.44 ± 0.09 | 0.46 ± 0.02 | 0.43 ± 0.08 | Liver (g) | 2.06 ± 0.12 | 1.19 ± 0.19 | 1.92 ± 0.20 | 2.09 ± 0.23 | 2.04 ± 0.23 | 2.04 ± 0.23 | Spleen (g) | 0,16 ± 0.02 | 0.21 ± 0.03 | 0.20 ± 0.04 | 0.19 ± 0.05 | 0.23 ± 0.10 | 0.23 ± 0.10 | Heart (g) | 0.16 ± 0.02 | 0.16 ± 0.04 | 0.16 ± 0.03 | 0.16 ± 0.03 | 0.14 ± 0.01 | 0.14 ± 0.01 | Lung (g) | 0.23 ± 0.04 | 0.21 ± 0.05 | 0.22 ± 0.03 | 0.26 ± 0.07 | 0.26 ± 0.03 | 0.26 ± 0.03 | Relative organ weight | Kidney (%) | 1.07 ± 0.10 | 1.22 ± 0.13 | 1.03 ± 0.09 | 1.14 ± 0.16 | 1.14 ± 0.19 | 1.14 ± 0.19 | Liver (%) | 5.30 ± 0.29 | 5.38 ± 0.42 | 4.99 ± 0.35 | 5.38 ± 0.25 | 5.40 ± 0.53 | 5.40 ± 0.53 | Spleen (%) | 0.41 ± 0.07 | 0.60 ± 0.07 | 0.51 ± 0.10 | 0.48 ± 0.11 | 0.61 ± 0.29 | 0.61 ± 0.29 | Heart (%) | 0.40 ± 0.04 | 0.44 ± 0.60 | 0.42 ± 0.06 | 0.41 ± 0.06 | 0.38 ± 0.03 | 0.38 ± 0.03 | Lung (%) | 0.59 ± 0.11 | 0.60 ± 0.13 | 0.59 ± 0.12 | 0.65 ± 0.11 | 0.67 ± 0.05 | 0.67 ± 0.05 |
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Data are expressed as means ± SD of five animals in each group.
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