Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.

Table 2

Body weight, organ weights, and relative organ weights of female rats treated orally with CECPM for 90 days.

Parameters	Groups
	Control	CECPM (600 mg/kg bw)	CECPM (800 mg/kg bw)	CECPM (1000 mg/kg bw)	Satellite
					Control	CECPM (1000 mg/kg bw)
Body weight
Initial weight (g)	181.62 ± 25.05	191.50 ± 25.53	185.52 ± 19.61	176.53 ± 22.65	195.08 ± 18.92	186.27 ± 16.92
Final weight (g)	226.33 ± 29.26	230.04 ± 22.03	226.69 ± 18.60	215.97 ± 27.26	245.27 ± 21.88	236.26 ± 16.70
Bogy weight gain (g)	44.71 ± 19.87	38.54 ± 13.06	41.17 ± 21.09	42.31 ± 16.00	50.19 ± 21.13	49.99 ± 15.46
Food intake (g)	20.68 ± 2.68	20.92 ± 1.77	20.35 ± 2.08	21.13 ± 2.67	21.25 ± 1.62	19.98 ± 1.77
Organ weight
Kidney (g)	1.47 ± 0.20	1.55 ± 0.27	1.48 ± 0.19	1.39 ± 0.16	1.55 ± 0.20	1.49 ± 0.11
Liver (g)	6.14 ± 1.02	6.63 ± 0.94	6.25 ± 0.75	5.99 ± 0.76	6.50 ± 0.69	6.60 ± 0.71
Spleen (g)	0,50 ± 0.07	0.48 ± 0.08	0.43 ± 0.06	0.51 ± 0.13	0.49 ± 0.08	0.44 ± 0.08
Heart (g)	0.79 ± 0.09	0.79 ± 0.14	0.76 ± 0.09	0.78 ± 0.09	0.84 ± 0.09	0.82 ± 0.08
Lung (g)	2.31 ± 0.59	2.45 ± 0.63	2.18 ± 0.66	2.28 ± 0.81	2.27 ± 0.65	2.07 ± 0.81
Relative organ weight
Kidney (%)	0.65 ± 0.03	0.67 ± 0.08	0.65 ± 0.04	0.65 ± 0.04	0.63 ± 0.07	0.63 ± 0.02
Liver (%)	2.71 ± 0.22	2.87 ± 0.17	2.75 ± 0.16	2.78 ± 0.14	2.66 ± 0.25	2.80 ± 0.24
Spleen (%)	0.22 ± 0.02	0.21 ± 0.03	0.19 ± 0.02^a	0.24 ± 0.05	0.20 ± 0.03	0.18 ± 0.03
Heart (%)	0.35 ± 0.03	0.21 ± 0.03	0.34 ± 0.03	0.36 ± 0.03	0.34 ± 0.03	0.35 ± 0.04
Lung (%)	1.03 ± 0.30	1.07 ± 0.27	0.96 ± 0.26	1.05 ± 0.33	0.93 ± 0.27	0.87 ± 0.33

Data are expressed as the means ± SD of ten animals in each group. ^a compared to the control group.