Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.

Table 3

Body weight, organ weights, and relative organ weights of male rats treated orally with CECPM for 90 days.

Parameters	Groups
	Control	CECPM (600 mg/kg bw)	CECPM (800 mg/kg bw)	CECPM (1000 mg/kg bw)	Satellite
					Control	CECPM (1000 mg/kg bw)
Body weight
Initial weight (g)	238.48 ± 23.93	249.43 ± 23.34	230.05 ± 37.29	240.30 ± 35.12	250.47 ± 19.35	235.70 ± 42.46
Final weight (g)	350.33 ± 42.92	339.27 ± 27.88	333.50 ± 29.34	341.06 ± 43.27	358.43 ± 34.22	365.22 ± 72.27
Body weight again (g)	111.85 ± 35.96	89.84 ± 30.99	103.45 ± 36.97	100.76 ± 36.11	107.96 ± 26.34	127.52 ± 84.31
Food intake (g)	26.56 ± 3.03	27.23 ± 3.41	21.10 ± 3.69	27.81 ± 3.39	28.04 ± 3.21	27.00 ± 2.90
Organ weight
Kidney (g)	2.33 ± 0.23	2.14 ± 0.21	2.14 ± 0.20	2.28 ± 0.29	2.20 ± 0.24	2.28 ± 0.43
Liver (g)	9.48 ± 1.45	8.96 ± 0.97	8.92 ± 1.03	9.53 ± 2.31	8.55 ± 2.94	10.73 ± 2.67
Spleen (g)	0,76 ± 0.14	0.67 ± 0.20	0.56 ± 0.07	0.66 ± 0.11	0.59 ± 0.13	0.60 ± 0.13
Heart (g)	1.03 ± 0.16	1.03 ± 0.09	1.02 ± 0.10	1.04 ± 0.14	1.01 ± 0.12	1.03 ± 0.17
Lung (g)	2.48 ± 0.66	2.51 ± 0.78	2.85 ± 1.00	3.60 ± 2.75	3.68 ± 1.04	2.91 ± 0.72
Relative organ weight
Kidney (%)	0.67 ± 0.03	0.63 ± 0.04	0.64 ± 0.03	0.67 ± 0.05	0.62 ± 0.05	0.63 ± 0.04
Liver (%)	2.70 ± 0.13	2.64 ± 0.09	2.67 ± 0.18	2.79 ± 0.51	2.39 ± 0.83	2.94 ± 0.24
Spleen (%)	0.22 ± 0.04	0.20 ± 0.04	0.17 ± 0.02^a	0.20 ± 0.03	0.16 ± 0.03	0.17 ± 0.02
Heart (%)	0.29 ± 0.03	0.30 ± 0.02	0.31 ± 0.02	0.31 ± 0.02	0.28 ± 0.02	0.28 ± 0.02
Lung (%)	0.70 ± 0.14	0.74 ± 0.22	0.85 ± 1.00	1.08 ± 0.87	1.04 ± 0.32	0.82 ± 0.21

Data are expressed as the means ± SD of ten animals in each group. ^a compared to the control group.