Acetylsalicylic Acid Promotes Osteogenic Differentiation of Human Dental Pulp Mesenchymal Stem Cells and Regeneration of Alveolar Bone in Experimental Periodontitis Rats

Figure 6

ASA activated JNK and p38 signaling pathways in hDPMSCs. (a–c) The protein expression of p-JNK, JNK, p-p38, p38, p-ERK, and ERK was examined by western blotting analysis in 0, 10, 30, and 60 min. (d–f) Quantification of p-JNK/JNK, 0 min vs. 10 min  = 0.0353; 10 min vs. 30 min  = 0.0197; 10 min vs. 60 min  = 0.0051; n = 3 for all the groups. p-p38/p38, 0 min vs. 10 min  = 0.0248; 10 min vs. 30 min  = 0.0029; n = 4 for all the groups. p-ERK/ERK, 0 min vs. 10 min  = 0.9899; 10 min vs. 30 min  = 0.8478; 10 min vs. 60 min  = 0.9998, n = 3 for all the groups. The results were expressed as the mean ± SD.  < 0.05;  < 0.01.

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