Mapping the Landscape of Magnetic Field Effects on Neural Regeneration and Repair: A Combined Systematic Review, Mathematical Model, and Meta-Analysis

Figure 4

Mathematical modeling and sensitivity analyses reveal NPC viability has a robust relationship with magnitude of magnetic field exposure. (a) Mathematical modeling and sensitivity analyses workflow. SMD = standardized mean difference; RMSE = root mean squared error; SD_pool = pooled standard deviation. For example, if the average value of a was 3 and only 3% of simulated a values were negative, we would say with confidence that there is a relationship between the independent and dependent variables. (b) Results from mathematical modeling. OD = oligodendrocytic differentiation; AD = astrocytic differentiation; ND = neuronal differentiation; V = neural stem/progenitor cell (NPC) viability; P = NPC proliferation; M = NPC maturation; Percent time = percentage of time exposed. Of note, no negative relationships were observed in our modeling results. (c) Sensitivity analysis results.

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