Solubilized Pancreatic Extracellular Matrix from Juvenile Pigs Protects Isolated Human Islets from Hypoxia-Induced Damage: A Viable Option for Clinical Islet Transplantation

Table 1

Islet characterization after 4-5 days of islet culture in hypoxic atmosphere (n = 8).

Treatments	Purity (%)	Overall survival (%)	ROS (FI/ng DNA)	Apoptosis (FI/ng DNA)	Stimulation index (20/2 mmol/L)	Total secretory potency (%)
Sham-treated	72.8 ± 15.1	33.6 ± 19.5	73.2 ± 51.1	29.5 ± 20.7	0.86 ± 0.33	100 ± 0
hEPM	89.0 ± 13.8^‡	53.3 ± 16.1^†,§	33.1 ± 32.6^‡	13.9 ± 7.4^†§	1.32 ± 0.21^†	302 ± 201^†
ppECM	86.7 ± 17.0^‡	72.3 ± 27.4^#	22.7 ± 16.1^‡	11.0 ± 6.6^#	1.47 ± 0.33^#	385 ± 218^#

^†, ^‡, ^# vs. sham-treated;^§ vs. ppECM; data are shown as mean ± SD.