Adherence to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana: A Randomised Trial of Supervised versus Unsupervised Drug Administration
Table 3
Reported side-effects within 7 day post first dose.
Symptom
Day 1*
Day 2
Day 3
Day 7
Sup.
Sup.
Unsup.
value
Sup.
Unsup.
value
Sup.
Unsup.
value
()
()
()
()
()
()
Headache
11.2
—
10.6
16.4
.12
7.3
11.5
.44
2.8
1.8
.56
Body weakness
15.5
—
13.6
7.9
.20
0.0
0.0
—
0.9
1.1
.87
Bodily pain
8.0
—
9.9
6.5
.22
5.7
8.8
.48
2.5
3.3
.64
Joint pain
6.6
—
8.0
10.4
.43
4.9
10.8
.22
4.0
1.7
.17
Drowsiness
5.1
—
4.2
7.8
.26
0.0
3.3
—
0.0
0.0
—
Uncontrollable body mov’t
2.0
—
10.3
5.9
.11
5.4
5.7
.94
2.0
2.2
.89
Nausea
1.0
—
2.9
3.0
.92
4.4
2.7
.57
1.5
3.6
.17
Abdominal pain
2.4
—
3.3
2.1
.46
1.3
1.4
.98
1.9
3.7
.27
Itching
1.4
—
0.0
2.0
—
1.3
0.0
.32
1.9
2.6
.63
Difficulty in sleeping
1.4
—
3.3
1.0
2.7
1.4
.57
3.3
6.3
.15
Lost of appetite
0.9
—
3.7
3.1
.72
6.6
3.9
.46
3.7
2.6
.51
Diarrhoea
0.0
—
2.3
1.0
.32
0.0
1.4
—
1.8
3.1
.40
Palpitation
0.9
—
1.4
0.5
.38
0.0
0.0
—
0.9
1.0
.89
Rash
0.5
—
0.0
0.0
—
0.0
0.0
—
0.5
0.5
.93
Vomiting
0.0
—
0.5
0.5
.94
0.0
0.0
—
0.0
0.0
—
*Unsupervised group were not assessed on day 1, Sup : supervised group; Unsup : Unsupervised group; Ave : average of supervised and unsupervised groups.
