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Journal of Tropical Medicine
Volume 2009, Article ID 832589, 7 pages
http://dx.doi.org/10.1155/2009/832589
Research Article

Insulin Growth Factor-I in Protein-Energy Malnutrition during Rehabilitation in Two Nutritional Rehabilitation Centres in Burkina Faso

1Institut de recherche en Sciences de la Santé, Centre national de la recherche Scientifique et Technologique, Ministère des Enseignements Secondaire, Supérieur et de la Recherché Scientifique, BP 7192 Ouagadougou, Burkina Faso
2Unité de Diabétologie et de Nutrition, Avenue Hippocrate 54, Bte 5474, 1200 Woluwe Saint Lambert, Brussels, Belgium
3Unité d'épidémiologie, biostatistique et méthodes opérationnelles en santé publique, Clos Chapelle aux Champs, 30, bte 3058, 1200 Woluwe-saint-Lambert, Brussels, Belgium

Received 2 November 2008; Accepted 15 January 2009

Academic Editor: Sasithon Pukrittayakamee

Copyright © 2009 S. Kouanda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the relationship between IGF-I and the nutritional status of West-African children hospitalised for nutritional rehabilitation. Patients and methods. A cohort study was performed in two centres for nutritional rehabilitation and education (CREN) in Burkina Faso. Children were followed and the anthropometric data as well as the capillary blood samples were taken on the 7th and on the 14th days after their admission. IGF-I levels were determined from dried blood spots on filter paper on IGF-I RIA, after separation of the IGF-I from its binding proteins, using Sep-Pak chromatography. Results. A total of 59 children was included in the cohort. The IGF-I mean geometric values (SD) were 6.3 (1.4) g/L on admission, 8.6 (1.8) g/L at day 7 and 13.6 (2.0) g/L at day 14. The differences between these values were statistically significant ( ). There is a significant correlation between the changes of IGF-I with the change of weight for height Z-score ( = .01). Conclusion. These results suggest that IGF-I can be considered as a potential marker to follow the nutritional status of children admitted in hospital for protein and energy malnutrition.