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Journal of Tropical Medicine
Volume 2011 (2011), Article ID 287914, 3 pages
http://dx.doi.org/10.1155/2011/287914
Case Report

Seizure and Hepatosplenomegaly—Rare Manifestation of Parvovirus B-19: A Case Report and Review of the Literature

1Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
2Department of Pediatric Gastroentology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India

Received 27 November 2010; Accepted 7 April 2011

Academic Editor: Jean-Paul Gonzalez

Copyright © 2011 Yadav Kamlesh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parvovirus B19 is the etiologic agent of erythema infectiosum (fifth disease), a fever-rash illness occurring in childhood. We present a 10 month old child with high grade fever for 10 days, generalized tonic-clonic seizure, bilateral cervical lymphadenopathy, generalized maculopapular rash, hematemesis and malena. Bone marrow aspiration and liver biopsy were done. EBV serology and parvovirus PCR were also performed. Bone marrow aspiration and biopsy showed giant pro-erythroblast consistent with parvovirus infection. PCR showed amplification of parvovirus genomic sequences. Present case highlights an atypical presentation of Parvovirus B19 infection as fever, rash and hepatosplenomegaly.