Review Article
Antimony Resistance in Leishmania, Focusing on Experimental Research
Table 1
Relevant molecular targets involved in Leishmania antimony resistance.
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The number of “+” signs is relative to the importance of the mechanism. For GCS and ODC, RNA-lowered expression is found only in one survey. MRPA: multidrug resistance related protein A. GCS: gammaglutamylcystein synthase. ODC: ornithine decarboxylase. Tryr: trypanothione reductase. Trper: tryparedoxin perxydase. AQP1: aquaglyceroporin1. LmACR2: Leishmania major antimony-arsenite reductase. |