Journal of Tropical Medicine

Review Article

Human Polymorphisms as Clinical Predictors in Leprosy

Table 1

Polymorphisms as predictors of leprosy clinical status and associated reactions. Most common human genetic polymorphisms irrespective of its ethnic origin [8, 21–31]. PB, paucibacillary; MB, multibacillary; RR, reversal reaction; ENL, erythema nodosum leprosum. Susceptibility alleles/genotypes/haplotypes are underlined, protection alleles/genotypes/haplotypes are not. (+), NS; associated but polymorphisms not specified; Ht, haplotype.
WHORidley-JoplinReactions
GenePer sePBMBTTLLMitsudaI (RR)II (ENL)
17q21-25(+), NS
C13orf31/
CCDC122		rs3764147
rs10507522
C3<1.1 mg/mL serum
C4AC4AF1
C4BC4B*Q0
CFBBfF
COL3A1250 bp/250 bp
CR14795 A/G
CTLA4104 bp
DEFB1668 C/G (−44, rs1800972)
FCN2Ht AGA (−986/−602/−4)
HLAA*0206, A*1102, B*4016, B*1801, B*5110, Cw*0407, Cw*0703, HLA-DRB1*1501HLAB46/MICA-A5Ht A*1102-B*4006-Cw*1502
HSPA1HSPA1A-A
IFNGIntron 1 CA
repeat, +874T
IL-4−590 T/C
IL-10AGC, TAC (−3575/
−2849/−2763)		819 C/T
−819 TT−592 C/A
IL12B3′UTR
1188 A/C
IL-12RB2−1035 A/G
−1023 A/G
−650 del/G
−464 A/G
KIRKIR2DS3
LAMA27809 T/C
LRRK2rs141938
LTA−294, −293, +10
, +80, +252, +368
LTA4Hrs1978331 T/C
rs2660898 T/G
MBL2Ht LYPA (−550L/221Y/+4P/exon1A)<100 ng/mL 161 G/A
MICA/MICBMICA-A5
MRC1rs1926736
G/A (396S)		Ht GAF (396/399/407)
rs2437257 C/G (407L)
NOD2rs12448797 T/C,
rs2287195 A/G 		rs2287195 A/G, rs8044354 A/G rs6500328 A/G
rs8044354 A/G,
rs13339578 G/A 		rs8043770 C/G, rs7194886 C/T rs7194886 C/T
rs4785225 C/G; rs751271 A/C
rs9302752/rs7194886		rs1861759 A/C, rs47852225 C/G rs17312836 A/C
rs751271 A/C rs1861758 C/T
rs1861759 A/C
PACRG
PARK2−697 G, −2599 T, −3024 C, −3800 G
rs1514343 T, rs1333955 C
, rs1040079 C
RIPK2rs42490
SLC11A1allele 23′UTR TGTG del(+), NS
TAPTAP2B
TIRAP180 S/L
TLR1T1805G, GG (I602S), 743 GG T1805G, (I602S)743 G
TLR2microsatellite 290 bp280 bp/280 bp, 597 C/T
Ht 280/297C/1350 T
TLR4896 G/A (D299G), 1530 G/T
1196 C/T (T399I)
TNFA(−308 G/A)−308 G/A−308 G/A>1000 pg/mL
VDRTT (TaqI)