Plasma Level of IL-4 Differs in Patients Infected with Different Modern Lineages of M. tuberculosis

Figure 2

Plasma cytokine and chemokine levels in TB cases infected with different lineages. Plasma samples from TB cases infected with lineage 3 (𝑛=22) and lineage 4 (𝑛=43) were assessed by multiplex cytokine analysis. (a) Anti-inflammatory cytokines (IL-10 and IL-4), (b) growth factors (EGF and VEGF), (c) pro-inflammatory cytokines (IFN-γ, IL 12 (p40), and TNF) and (d) chemokines (IP-10, MCP-1, MCP-3, MIP-1β and fractalkine). Horizontal line indicates median levels of TB cases infected with lineage 3 (filled circles) and lineage 4 (open circles). data were analysed using nonparametric Mann-Whitney test with 𝑃 values indicating significant differences after data were trimmed and transformed to Log 2 values. *𝑃<0.05.

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