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Journal of Tropical Medicine
Volume 2012 (2012), Article ID 519701, 5 pages
Clinical Study

Leptospirosis Prevalence in Patients with Initial Diagnosis of Dengue

1Coordinación de Vigilancia Epidemiológica y Apoyo en Contingencias, Unidad de Salud Pública, Instituto Mexicano del Seguro Social (IMSS), 03100, Mexico City, DF, Mexico
2Coordinación de Salud Pública, Delegación Veracruz Norte, IMSS, 91810, Mexico City, DF, Mexico
3Coordinación de Investigación en Salud, Delegación Veracruz Norte, IMSS, 91000, Mexico City, DF, Mexico
4Clínica de Medicina Tropical, Unidad de Medicina Experimental, Facultad de Medicina, UNAM, 06700, Mexico City, DF, Mexico
5Centro de Investigación en Micro y Nanotecnología, Universidad Veracruzana, 94294, Xalapa, VER, Mexico

Received 22 December 2011; Revised 23 February 2012; Accepted 23 February 2012

Academic Editor: Jean-Paul Gonzalez

Copyright © 2012 A. Dircio Montes Sergio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine the prevalence of leptospirosis in patients from Veracruz with initial diagnosis of dengue and its association with risk factors. Materials and Methods. Transversal study in patients who sought medical attention under the suspicion of dengue. Backgrounds were researched and blood samples were drawn to determine dengue (NS1, RT-PCR) and leptospirosis (IFI). Simple frequencies, central tendency and dispersion measures, and prevalence and trust intervals at 95% (IC95%) were obtained. Prevalence reasons (RP) and IC95% were obtained and a multivariate logistic model was applied, using SPSS V15. Results. 171 patients were included, 56% women ( 3 2 ± 1 4 years) and 44% men ( 3 2 ± 1 7 years). 48% of the cases (IC95% 40.5–55.4) was positive to dengue, with a cut point of 1 : 80, seroprevalence for leptospirosis was of 6% (IC95% 2.7–10); 12% (IC95% 7–16.5) was positive to both pathologies and 34% was negative to both tests. Although the largest number of isolations corresponded to serotype 2, the four dengue virus serotypes were identified. In the bivariate analysis, overcrowding RP = 1.33, (IC = 0.46–3.5), bathing in rivers (RP = 1.31, IC = 0.13–7.4), and walking barefoot (RP = 1.39, IC = 0.58–3.3) were the variables associated with leptospirosis, although the relation was not statistically significant. Conclusions. Leptospirosis prevalence in subjects under suspicion of dengue fever is high, as well as the coincidence of both infections. The results show the coexistence of overlapped outbreaks of several diseases sharing the side of transmission. It is necessary the intentional search of other pathologies, such as influenza, rickettsiosis, and brucella, among others.