Dengue Virus Entry as Target for Antiviral Therapy

Figure 2

Structure of DC-SIGN. DC-SIGN, mainly expressed by human dendritic cells in the skin, is composed out of four domains: (A) cytoplasmic domain containing internalization signals, (B) transmembrane domain, (C) 7 or 8 extracellular neck repeats implicated in the oligomerization of DC-SIGN, and (D) carbohydrate recognition domain which can interact calcium-dependently with a variety of pathogens.