Moving “Forward” in Plasmodium Genetics through a Transposon-Based Approach

Figure 3

An example of a successful forward genetic approach in P. falciparum. A screen for attenuated intraerythrocytic growth indicates the significance of post-transcriptional gene regulation in these stages. Functional characterization of CCR4-Associated Factor 1 has revealed a role in temporal regulation of gene expression in P. falciparum, implying its importance in intraerythrocytic development.