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Journal of Tropical Medicine
Volume 2013, Article ID 213490, 6 pages
Research Article

Children with Kaposi Sarcoma in Two Southern African Hospitals: Clinical Presentation, Management, and Outcome

Department of Pediatrics and Child Health, Tygerberg Children’s Hospital, Stellenbosch University, P.O. Box 19063, Tygerberg, Cape Town 7550, South Africa

Received 20 August 2013; Accepted 12 November 2013

Academic Editor: Shyam Sundar

Copyright © 2013 G. P. De Bruin and D. C. Stefan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. In 2010 more than 3 million children with human immunodeficiency virus (HIV) were living in Sub-Saharan Africa. The AIDS epidemic has contributed to an abrupt increase of the frequency of Kaposi sarcoma (KS), especially in Southern Africa. There is a need to describe the clinical features of this disease, its management, and its outcome in HIV positive children in Southern Africa. The aim of the study is to describe two different populations with HIV and KS from two African hospitals in Namibia and South Africa. Material and Methods. A retrospective descriptive study of patients with KS who presented to Tygerberg Hospital (TH) and Windhoek Central Hospital (WCH) from 1998 to 2010. Demographic data, HIV profile, clinical picture of KS, and survival were documented. Results. The frequency of KS declined from 2006 to 2010 in TH but showed an increase in the same period in WCH. Children in TH were diagnosed at a much younger age than those in WCH (44.2 months versus 90 months). Cutaneous lesions were the most common clinical presenting feature, followed by lymphadenopathy, intrathoracic and oral lesions. Conclusions. The clinical characteristics of KS in South Africa and Namibia differ in many aspects between the 2 countries.