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Journal of Tropical Medicine
Volume 2013, Article ID 648475, 11 pages
Research Article

HLA-B*44 Is Associated with Dengue Severity Caused by DENV-3 in a Brazilian Population

1Virology and Experimental Therapy Laboratory, Aggeu Magalhães Research Center, Fiocruz, Avenida Moraes Rego s/n, Campus da UFPE, Cidade Universitária, 50670-420 Recife, PE, Brazil
2Department of Electrical Engineering, Texas A&M University, 3128 TAMU, Station College Station, TX 77843-3128, USA
3Department of Infectious Diseases and Microbiology, Center for Vaccine Research, University of Pittsburgh, 3501 Fifth Avenue, Biomedical Science Tower 3, Room 9022, Pittsburgh, PA 15261, USA
4Central Laboratory of Public Health, Secretaria de Saúde do Estado de Pernambuco, Praça Oswaldo Cruz s/n, Boa Vista, 50050-210 Recife, PE, Brazil
5Hospital das Clínicas, Universidade Federal de Pernambuco, Clínica Médica, Avenida Morais Rego s/n, Campus da UFPE, Cidade Universitária, 50670-420 Recife, PE, Brazil
6Departamento de Bioquímica e Biofísica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Moraes Rêgo 1235, Cidade Universitária, 50670-420 Recife, PE, Brazil
7Departamento de Imunologia do Centro de Pesquisas Aggeu Magalhães-CPqAM, Fiocruz, Avenida Moraes Rego s/n, Campus da UFPE, Cidade Universitária, 50670-420 Recife, PE, Brazil

Received 31 January 2013; Revised 11 April 2013; Accepted 15 April 2013

Academic Editor: Jean-Paul Gonzalez

Copyright © 2013 Liciana Xavier Eurico de Alencar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Human leukocyte antigen (HLA) alleles have been correlated with susceptibility or resistance to severe dengue; however, few immunogenetic studies have been performed in Latin American (LA) populations. We have conducted immunogenetic studies of HLA class I and II alleles in a cohort of 187 patients with DENV-3 infection and confirmed clinical diagnosis of either severe dengue, known as dengue hemorrhagic fever (DHF), or the less severe form, dengue fever (DF), in Recife, Pernambuco, Brazil. An association analysis was performed using Fisher’s association test, with odds ratios (ORs) calculated using conditional maximum likelihood estimates. HLA-B*44 ( , OR = 2.025, 95% CI = 0.97–4.24) was found to be associated with increased susceptibility to DHF in response to DENV-3 infection. In addition, HLA-B*07 ( , OR = 0.501, one-sided 95% CI = 0–0.99) and HLA-DR*13 ( , OR = 0.511, one-sided 95% CI = 0–0.91) were found to be associated with resistance to secondary dengue infection by DENV-3. These results suggest that HLA-B*44 supertype alleles and their respective T-cell responses might be involved in susceptibility to severe dengue infections, whereas the HLA-B*07 supertype alleles and DR*13 might be involved in cross-dengue serotype immunity.