Elevated Dengue Virus Nonstructural Protein 1 Serum Levels and Altered Toll-Like Receptor 4 Expression, Nitric Oxide, and Tumor Necrosis Factor Alpha Production in Dengue Hemorrhagic Fever Patients

Figure 6

Toll-like receptor (TLR-4) expression of CD14⁺ cells from patients () infected with dengue virus during the acute phase of the disease. (a) represents the gate strategy: a gate was drawn on SSC × FL1/CD14⁺ cells. (b) represents anti-TLR4-PE mean fluorescence intensity (MFI) of CD14⁺ cells from dengue fever (DF, ), dengue hemorrhagic fever (DHF, ), and healthy controls (HC, ). (c) represents anti-TLR4-PE MFI of CD14⁺ cells from dengue infected patients with low (NS1 < 100 × 10³ BRU/mL) and high (NS1 ≥ 100 × 10³ BRU/mL) dengue virus nonstructural protein 1 (NS1) serum levels. Results on (b) and (c) graphs were expressed as median using a box plot. Equivalent symbols (, #) represent statistically significant differences () between groups.

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