Evidence of HLA-DQB1 Contribution to Susceptibility of Dengue Serotype 3 in Dengue Patients in Southern Brazil
Table 2
Comparison of the frequencies of class II HLA alleles between the control group and patients with clinical-serologic diagnoses of dengue infection in the South of Brazil, occurring in 2007 during a serotype 3 virus epidemic.
HLA
Patients (95)
Controls (173)
%
%
DRB101
23
12.1
38
11.0
DRB103
20
10.5
40
11.6
DRB104
25
13.2
33
9.5
DRB107
23
12.1
38
11.0
DRB108
8
4.2
20
5.8
DRB109
7
3.7
4
1.2
DRB110
4
2.1
8
2.3
DRB111a
16
8.4
56
16.2
DRB112
3
1.6
5
1.4
DRB113
21
11.1
49
14.2
DRB114
9
4.7
24
6.9
DRB115b
21
11.1
19
5.5
DRB116
10
5.3
12
3.5
HLA
Patients (95)
Controls (173)
%
%
HLA-DQA01:01
38
20.0
65
18.8
HLA-DQA01:02
37
19.5
51
14.7
HLA-DQA01:03
11
5.8
23
6.6
HLA-DQA01:06
0
0.0
2
0.6
HLA-DQA02:01
24
12.6
35
10.1
HLA-DQA04:01
31
16.3
39
11.3
HLA-DQA05:01c
8
4.2
21
6.1
HLA-DQA05:10
40
21.1
107
30.9
HLA-DQA06:01
0
0.0
1
0.3
HLA
Patients (96)
Controls (173)
%
%
HLA-DQB102:01
19
9.9
37
10.7
HLA-DQB102:02
26
13.5
34
9.8
HLA-DQB102:03
1
0.5
1
0.3
HLA-DQB103:01
30
15.6
73
21.1
HLA-DQB103:02
19
9.9
26
7.5
HLA-DQB103:03
3
1.6
5
1.4
HLA-DQB103:04
1
0.5
0
0.0
HLA-DQB103:05
1
0.5
1
0.3
HLA-DQB103:19
0
0.0
4
1.2
HLA-DQB103:22
0
0.0
1
0.3
HLA-DQB103:26
1
0.5
0
0.0
HLA-DQB104:01
0
0.0
3
0.9
HLA-DQB104:02
6
3.1
20
5.8
HLA-DQB105:01
31
16.1
50
14.5
HLA-DQB105:02
4
2.1
10
2.9
HLA-DQB105:03
12
6.3
20
5.8
HLA-DQB105:05
1
0.5
0
0.0
HLA-DQB106:01
20
10.4
34
9.8
HLA-DQB106:02
4
2.1
15
4.3
HLA-DQB106:03
1
0.5
8
2.3
HLA-DQB106:09
0
0.0
4
1.2
HLA-DQB106:11d
12
6.3
0
0.0
: allelic number. , OR = 0.48 (CI 95% = 0.27–0.86); , OR = 2.14 (CI 95% = 1.12–4.09); , OR = 0.60 (CI 95% = 0.39–0.90); , OR = 46.13 (CI 95% = 2.71–785.3), = .
