Table of Contents Author Guidelines Submit a Manuscript
Journal of Tropical Medicine
Volume 2015, Article ID 796182, 11 pages
http://dx.doi.org/10.1155/2015/796182
Research Article

Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia

Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Calle 70, No. 52-21, Medellín, Colombia

Received 30 June 2015; Revised 4 October 2015; Accepted 20 October 2015

Academic Editor: Ib C. Bygbjerg

Copyright © 2015 Alberto Tobón-Castaño et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, Global Malaria Action Plan for a Malaria-Free World. Geneva, Switzerland: Roll Back Malaria Partnership; 2008, World Health Organization, 2008.
  2. WHO, World Malaria Report 2014, World Health Organization, 2014.
  3. The Lancet, “New estimates of malaria deaths: concern and opportunity,” The Lancet, vol. 379, no. 9814, p. 385, 2012. View at Publisher · View at Google Scholar
  4. R. N. Price, N. M. Douglas, and N. M. Anstey, “New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance,” Current Opinion in Infectious Diseases, vol. 22, no. 5, pp. 430–435, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Picot and A.-L. Bienvenu, “Plasmodium vivax infection: not so benign,” Medecine/Sciences, vol. 25, no. 6-7, pp. 622–626, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. V. G. Lacerda, M. P. G. Mourão, H. C. Coelho, and J. B. Santos, “Thrombocytopenia in malaria: who cares?” Memorias do Instituto Oswaldo Cruz, vol. 106, supplement 1, pp. 52–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. P. Quintero, A. M. Siqueira, A. Tobón et al., “Malaria-related anaemia: a Latin American perspective,” Memorias do Instituto Oswaldo Cruz, vol. 106, supplement 1, pp. 91–104, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. E. L. Martínez-Salazar and A. Tobón-Castaño, “Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 47, no. 3, pp. 341–349, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. D. C. Dale and S. M. Wolff, “Studies of the neutropenia of acute malaria,” Blood, vol. 41, no. 2, pp. 197–206, 1973. View at Google Scholar · View at Scopus
  10. T. Hänscheid, M. Längin, B. Lell et al., “Full blood count and haemozoin-containing leukocytes in children with malaria: diagnostic value and association with disease severity,” Malaria Journal, vol. 7, article 109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. F. E. McKenzie, W. A. Prudhomme, A. J. Magill et al., “White blood cell counts and malaria,” Journal of Infectious Diseases, vol. 192, no. 2, pp. 323–330, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Modiano, B. S. Sirima, A. Konaté, I. Sanou, and A. Sawadogo, “Leucocytosis in severe malaria,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 95, no. 2, pp. 175–176, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. W. R. J. Taylor, H. Widjaja, H. Basri et al., “Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria,” Malaria Journal, vol. 7, article 259, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. N. Wickramasinghe and S. H. Abdalla, “Blood and bone marrow changes in malaria,” Baillieres Best Practice and Research in Clinical Haematology, vol. 13, no. 2, pp. 277–299, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Tangpukdee, H.-S. Yew, S. Krudsood et al., “Dynamic changes in white blood cell counts in uncomplicated Plasmodium falciparum and P. vivax malaria,” Parasitology International, vol. 57, no. 4, pp. 490–494, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. González, H. Rodulfo, M. De Donato, M. Berrizbeitia, C. Gómez, and L. González, “Variaciones hematológicas en pacientes con malaria causada por Plasmodium vivax antes, durante y después del tratamiento,” Investigación Clínica, vol. 50, no. 2, pp. 187–201, 2009. View at Google Scholar
  17. S. Ladhani, B. Lowe, A. O. Cole, K. Kowuondo, and C. R. J. C. Newton, “Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome,” British Journal of Haematology, vol. 119, no. 3, pp. 839–847, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. Q. De Mast, F. C. G. J. Sweep, M. McCall et al., “A decrease of plasma macrophage migration inhibitory factor concentration is associated with lower numbers of circulating lymphocytes in experimental Plasmodium falciparum malaria,” Parasite Immunology, vol. 30, no. 3, pp. 133–138, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Helmby, G. Jönsson, and M. Troye-Blomberg, “Cellular changes and apoptosis in the spleens and peripheral blood of mice infected with blood-stage Plasmodium chabaudi chabaudi AS,” Infection and Immunity, vol. 68, no. 3, pp. 1485–1490, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Mohan and M. M. Stevenson, “Dyserythropoiesis and severe anaemia associated with malaria correlate with deficient interleukin-12 production,” British Journal of Haematology, vol. 103, no. 4, pp. 942–949, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. C. J. Gregory, O. D. Lorenzi, L. Colón et al., “Utility of the tourniquet test and the white blood cell count to differentiate dengue among acute febrile illnesses in the emergency room,” PLoS Neglected Tropical Diseases, vol. 5, no. 12, Article ID e1400, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Campuzano, “Del hemograma manual al hemograma de cuarta generación,” Medicina & Laboratorio, vol. 13, pp. 511–550, 2007. View at Google Scholar
  23. G. Campuzano, Utilidad del Extendido de Sangre Periférica: Los Leucocitos, vol. 14, Medicina & Laboratorio, 2008.
  24. A. Tobón, C. Giraldo, J. G. Piñeros, M. Arboleda, S. Blair, and J. Carmona-Fonseca, “The epidemiology of complicated falciparum malaria: case and controls study in Tumaco and Turbo, Colombia, 2003,” Revista Brasileira de Epidemiologia, vol. 9, no. 3, pp. 283–296, 2006. View at Google Scholar · View at Scopus
  25. S. Blair, G. Álvarez, and G. Campuzano, “Relación entre anemia y malaria en una población rural de Colombia,” Boletín de Malariología y Salud Ambiental (Venezuela), no. 37, pp. 7–13, 1997. View at Google Scholar
  26. A. Tobón-Castaño, C. Giraldo-Castro, and S. Blair, “Prognostic value of clinical and parasitological signs for severe malaria in patients from Colombia,” Biomédica, vol. 32, supplement 1, pp. 79–94, 2012. View at Google Scholar · View at Scopus
  27. F. J. Lopez Antuñano and G. Schmunis, Diagnóstico de Malaria, Publicación Científica no. 512, OMS, Washington, DC, USA, 1988.
  28. G. Campuzano, “Interpretación del hemograma automatizado: claves para una mejor utilización de la prueba,” Medicina & Laboratorio, vol. 19, no. 1-2, pp. 11–68, 2013. View at Google Scholar
  29. WHO, “Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 94, supplement 1, pp. S1–S90, 2000. View at Google Scholar
  30. B. E. Barber, T. William, M. J. Grigg et al., “Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria,” PLoS Pathogens, vol. 11, no. 1, Article ID e1004558, 2015. View at Publisher · View at Google Scholar
  31. R. N. Rodrigues-da-Silva, J. D. C. Lima-Junior, B. D. P. F. e Fonseca et al., “Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections,” Memórias do Instituto Oswaldo Cruz, vol. 109, no. 2, pp. 154–162, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. C. G. Reiley and O. Barrett Jr., “Leukocyte response in acute malaria,” The American Journal of the Medical Sciences, vol. 262, no. 3, pp. 153–158, 1971. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Eriksson, U. Hellgren, and L. Rombo, “Changes in erythrocyte sedimentation rate, C-reactive protein and hematological parameters in patients with acute malaria,” Scandinavian Journal of Infectious Diseases, vol. 21, no. 4, pp. 435–441, 1989. View at Publisher · View at Google Scholar · View at Scopus
  34. U. M. Jadhav, R. Singhvi, and R. Shah, “Prognostic implications of white cell differential count and white cell morphology in Malaria,” Journal of Postgraduate Medicine, vol. 49, no. 3, pp. 218–220, 2003. View at Google Scholar · View at Scopus
  35. L. H. Camacho, P. Wilairatana, G. Weiss et al., “The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria,” Tropical Medicine and International Health, vol. 4, no. 7, pp. 471–475, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Goldstein, “A clinical study of falciparum and vivax malaria in Vietnam servicemen,” Military Medicine, vol. 133, no. 12, pp. 991–996, 1968. View at Google Scholar · View at Scopus
  37. A. Rasheed, S. Saeed, and S. A. Khan, “Clinical and laboratory findings in acute malaria caused by various plasmodium species,” Journal of the Pakistan Medical Association, vol. 59, no. 4, pp. 220–223, 2009. View at Google Scholar · View at Scopus
  38. L. W. P. Church, T. P. Le, J. P. Bryan et al., “Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge,” Journal of Infectious Diseases, vol. 175, no. 4, pp. 915–920, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. M. W. Richards, R. H. Behrens, and J. F. Doherty, “Short report: hematologic changes in acute, imported Plasmodium falciparum malaria,” The American Journal of Tropical Medicine and Hygiene, vol. 59, no. 6, p. 859, 1998. View at Google Scholar · View at Scopus
  40. L. Schofield, L. Vivas, F. Hackett, P. Gerold, R. T. Schwartz, and S. Tachado, “Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-α-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria,” Annals of Tropical Medicine and Parasitology, vol. 87, no. 6, pp. 617–626, 1993. View at Google Scholar · View at Scopus
  41. A. R. Miller, J. Suttles, and R. D. Stout, “Cytokine priming reduces dependence on TNF-R2 for TNF-α-mediated induction of macrophage nitric oxide generation,” Journal of Interferon and Cytokine Research, vol. 16, no. 12, pp. 1055–1063, 1996. View at Google Scholar · View at Scopus
  42. H. H. Simms, T. A. Gaither, L. F. Fries, and M. M. Frank, “Monokines released during short-term FCγ receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function,” Journal of Immunology, vol. 147, no. 1, pp. 265–272, 1991. View at Google Scholar · View at Scopus
  43. I. M. Elhassan, L. Hviid, G. Satti et al., “Evidence of endothelial inflammation, T cell activation, and T cell reallocation in uncomplicated Plasmodium falciparum malaria,” The American Journal of Tropical Medicine and Hygiene, vol. 51, no. 3, pp. 372–379, 1994. View at Google Scholar · View at Scopus
  44. L. Hviid, J. A. L. Kurtzhals, B. Q. Goka, J. O. Oliver-Commey, F. K. Nkrumah, and T. G. Theander, “Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria,” Infection and Immunity, vol. 65, no. 10, pp. 4090–4093, 1997. View at Google Scholar · View at Scopus
  45. J. Matsumoto, S. Kawai, K. Terao et al., “Malaria infection induces rapid elevation of the soluble Fas ligand level in serum and subsequent T lymphocytopenia: possible factors responsible for the differences in susceptibility of two species of Macaca monkeys to Plasmodium coatneyi infection,” Infection and Immunity, vol. 68, no. 3, pp. 1183–1188, 2000. View at Publisher · View at Google Scholar · View at Scopus
  46. P. Kern, M. Dietrich, C. Hemmer, and N. Wellinghausen, “Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria,” Infection and Immunity, vol. 68, no. 5, pp. 3061–3063, 2000. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Hviid, K. Kemp, P. Kern et al., “What is the cause of lymphopenia in malaria?” Infection and Immunity, vol. 68, no. 10, pp. 6087–6089, 2000. View at Publisher · View at Google Scholar · View at Scopus
  48. J. A. L. Kurtzhals, C. M. Reimert, E. Tette et al., “Increased eosinophil activity in acute Plasmodium falciparum infection—association with cerebral malaria,” Clinical & Experimental Immunology, vol. 112, no. 2, pp. 303–307, 1998. View at Publisher · View at Google Scholar · View at Scopus
  49. Q. de Mast, E. Groot, P. J. Lenting et al., “Thrombocytopenia and release of activated von Willebrand factor during early Plasmodium falciparum malaria,” Journal of Infectious Diseases, vol. 196, no. 4, pp. 622–628, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. N. Karunaweera, D. Wanasekara, V. Chandrasekharan, K. Mendis, and R. Carter, “Plasmodium vivax: paroxysm-associated lipids mediate leukocyte aggregation,” Malaria Journal, vol. 6, article 62, 2007. View at Publisher · View at Google Scholar · View at Scopus