Clinical Study
Short-Course Induction Treatment with Intrathecal Amphotericin B Lipid Emulsion for HIV Infected Patients with Cryptococcal Meningitis
Table 2
Univariate and multivariate analysis of factors associated with mortality using Cox proportional hazard methods.
| | | Hazard ratio | Adjusted hazard ratio |
| | Female | 0.794 (0.442–1.424) | 0.800 (0.431–1.484) | | AMS or seizures | 2.337 (1.394–3.918) | 1.716 (0.982–2.998) | | CD4 count (cells/mcl) | | | | 0–25 | 1 (reference) | 1 (reference) | | 26–50 | 1.115 (0.551–2.255) | 0.875 (0.405–1.892) | | 51–100 | 0.903 (0.395–2.064) | 1.116 (0.476–2.614) | | 100 | 1.020 (0.522–1.993) | 0.970 (0.487–1.934) | | On ART | 0.896 (0.54–1.486) | 1.012 (0.588–1.739) | | Age (years) | 1.015 (0.989–1.043) | 1.013 (0.985–1.042) | | WBC (cells/nL) | 1.097 (1.054–1.143) | 1.147 (1.092–1.204) | | Haemoglobin (g/dL) | 0.922 (0.820–1.036) | 0.860 (0.758–0.976) | | CSF WC (cells/mL) | 0.995 (0.991–0.999) | 0.995 (0.992–0.999) | | Treatment | | | | Standard | 1 (reference) | 1 (reference) | | Short i.t. course | 0.496 (0.276–0.890) | 0.403 (0.215–0.756) |
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value < 0.05. AMS: altered mental status; ART: antiretroviral therapy; CSF WC: cerebrospinal fluid white cells; i.t.: intrathecal; Rx: treatment; WBC: white blood cells.
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