Antibiotic Resistance in Streptococcus pneumoniae after Azithromycin Distribution for Trachoma

Table 1

Characteristics of included studies.

Source	Country	Treatment group	Age range	Numbers treated	Control group	Treatment frequency	Measures baseline	Follow-up	Sample population	Test kit for resistance
Leach et al. 1997 [16]	Australia	Children with trachoma and their household contacts who were children	<15 years old	130	No	Single	Yes	2-3 weeks; 2 months; 6 months	All children <15 years old with trachoma	E-test© strips
Fry et al. 2002 [17]	Nepal	All children	1–10 years old	169	No	Single	Yes	10 days; 180 days	Randomly selected 1–10-year-old children	—
Batt et al. 2003 [18]	Tanzania	All nonpregnant individuals	>1 year old	4782	No	Single	Yes	2 months; 6 months	All children <7 year old	E-test© strips
Gaynor et al. 2003 [19]	Nepal	All children with clinically active trachoma and all household members of these children	1–10 years old	94	No	Single	No	1 year	Randomly selected 1–10-year-old children	E-test© strips
Gaynor et al. 2005 [20]	Nepal	All children	1–10 years old	194	Yes	Annual ×3	No	6 months	All children aged 1–7 years	Sensititre© MIC plates
Haug et al. 2010 [21]	Ethiopia	All nonpregnant individuals	>1 year old	Not known	Yes	Biannual ×6	No	6 months; 12 months; 24 months	Randomly selected 1–5-year-old children	Sensititre© MIC plates
Skalet et al. 2010 [22]	Ethiopia	All children	1–10 years old	3830	Yes	Quarterly ×4	Yes	3 months	Randomly selected <10-year-old children	E-test© strips
Coles et al. 2013 [23]	Tanzania	All children in MDA villages	<5 years old	467	Yes	Single	Yes	1 month; 3 months; 6 months	Randomly selected 2–5-year-old children	E-test© strips