Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review

Table 3

Challenges of curcumin use in clinical setting.

Challenge	References
Cytotoxicity
DNA damage and chromosome aberrations	[50–53]
Carcinogenesis
Promote tumour formation in vivo	[54, 55]
Iron chelation
Alter systemic iron metabolism	[56]
Enzyme inhibition
Inhibit drug-metabolizing enzymes	[57, 58]
Solubility
Hydrophobic nature does not support water solubility	[59, 60]
Bioavailability
Degradation by plasma protease and nonspecific protein binding	[26, 27, 61, 62]