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Journal of Tropical Medicine
Volume 2016, Article ID 8738972, 6 pages
Research Article

Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei

1Department of Biochemistry, University of Agriculture, Makurdi, Nigeria
2Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
3Directorate of Research and Development, Nigerian Institute of Leather and Science Technology, Zaria, Nigeria

Received 12 August 2016; Revised 2 November 2016; Accepted 3 November 2016

Academic Editor: Marcel Tanner

Copyright © 2016 Oche Okpe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The study determined if administration of Vernonia amygdalina and Carica papaya plants provides synergistic effects in ameliorating plasmodium infection in mice. Thirty mice (17.88–25.3 g) were divided into 6 groups of 5 mice each. Group 1 was normal control, while groups 2–6 were intraperitoneally inoculated 2.5 × 107 Plasmodium berghei parasitized red blood cell, followed by daily administration of 350 mg/kg aqueous leaf extracts after establishment of infection. Group 2 was disease control, while group 6 was treated with standard drug for four consecutive days. The results showed significant () reduction in percentage of parasite load between the infected treatment groups and disease control group at day 3 after infection, which remained consistent until the end of the experiment. All infected treated groups showed significant () increases in RBC and PCV recovery compared to the disease control, with the exception of WBC. There was insignificant () change in mean body weight of all treated groups except in disease control group. Histological studies of the infected mice indicate recovery of hepatic cells from congested black pigmentation. The reduction in parasite load and recovery of hepatic cell damage/hematological parameters were induced by these plant extracts. This highlighted the important usage of the plant in traditional remedy of malaria infection.