Research Article

Submicroscopic and Asymptomatic Congenital Infection by Plasmodium vivax or P. falciparum in Colombia: 37 Cases with Placental Histopathology and Cytokine Profile in Maternal and Placental Blood

Table 4

Placental histological findings according to the presence of Plasmodium in cord.
(a) Prevalence of histologic event

Sector/eventPlasmodium in cord
NoYes

Deciduan = 100%n = 37%
 Immune cells616126700.317
 Atherosis464612320.254
 Necrosis22130.803
 Abruptio494913350.148

Villi
 Infarction848431840.976
 Edema868626700.034

IVS
 Immune cells1001001001001.000
 Hemorrhage959536970.560
 Thrombosis505018490.888
 Calcifications707025680.784

In the villi, the following variables were also evaluated: (1) villi/field, (2) capillaries/villus, (3) immune cells, (4) fibrinoid deposits, and (5) syncytial knots. In all placentas, these variables were always present and therefore we do not apply the presentation in terms of present versus absent. The event is always present, either with or without the presence of Plasmodium infection, which varies in the magnitude of the event.
(b) Quantitative comparison of the variables

PlasmodiumMeanSDSE

Decidua
 Immune cellsNo0.570.8350.080.001
Yes1.211.1160.183
 AtherosisNo0.030.030.0030.226
Yes0.020.030.005
 NecrosisNo0.00050.0030.00030.804
Yes0.00060.0040.0007
 AbruptioNo0.060.080.0080.072
Yes0.030.070.01

Villi
 Immune cellsNo0.700.5150.050.059
Yes0.870.5330.09
 Fibrinoid depositsNo1.840.5910.060.764
Yes1.860.6710.110
 Syncytial knotsNo3.001.3670.1370.239
Yes2.721.1810.194
 Villi/fieldNo8.741.5510.1550.442
Yes8.501.8720.308
 Capillaries/villusNo3.911.1680.1170.589
Yes4.021.4560.182

Intervillous space
 Immune cellsNo2.291.4580.1460.100
Yes2.711.5340.252
 HemorrhageNo0.360.2060.020.639
Yes0.340.2080.03
 ThrombiNo0.030.060.0060.838
Yes0.030.050.008
 CalcificationsNo0.210.3740.040.761
Yes0.210.3730.06