Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits

Table 1

Percentages of Plasmodium falciparum (W2) parasitemia reduction at 50 μg⋅mL⁻¹ and 25 μg⋅mL⁻¹ for naphthoquinones 6a–h, 7a–h, 8a–h, 9, and 10a–c.

Compound	% reduction at 50 μg⋅mL^−1	% reduction at 25 μg⋅mL^−1
6a	75	53
6b	73	80
6c	64	50
6d	91	81
6e	71	53
6f	64	54
6g	78	73
6h	83	58
7a	98	98
7b	90	81
7c	94	91
7d	81	81
7e	94	88
7f	81	75
7g	79	18
7h	95	89
8a	83	75
8b	85	78
8c	92	86
8d	71	70
8e	83	76
8f	87	85
8g	80	78
8h	62	24
9	61	34
10a	21	9
10b	22	16
10c	15	12