Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana

Table 1

Product characteristics of the essential children’s medicines investigated.

Product and code	Labeled; strength	Country of manufacture	Batch; number	Manufacturing; date	Expiry date	FDA/PML; number
Ciprofloxacin
CPF1	250 mg/5 ml	UK	0710069	06/2015	05/2017	Yes
CPF2	250 mg/5 ml	India	-	06/2014	05/2017	No
Cotrimoxazole
CTX1	125 mg/5 ml	UK	EXMT 002	09/2014	08/2017	No
CTX2	125 mg/5 ml	India	XT 029	02/2015	01/2018	Yes
CTX3	125 mg/5 ml	Ghana	0302R	02/2015	02/2018	No
CTX4	125 mg/5 ml	Ghana	15012	08/2015	08/2018	Yes
CTX5	125 mg/5 ml	Ghana	0250495	05/2015	04/2017	Yes
Metronidazole
MTZ1	200 mgt/5 ml	South Africa	46159A	12/2014	11/2016	Yes
MTZ2	200 mg/5 ml	Ghana	X-214	03/2015	03/2017	Yes
MTZ3	200 mg/5 ml	UK	MTXT-002	10/2014	09/2017	No
MTZ4	200 mg/5 ml	Ghana	0403R	03/2015	03/2017	No
MTZ5	200 mg/5 ml	Ghana	15002	04/2015	04/2018	Yes
MTZ6	200 mg/5 ml	Ghana	0260385	07/2015	06/2017	Yes
Amoxicillin
AMX1	125 mg/5 ml	UK	676164	11/2013	11/2018	No
AMX2	125 mg/5 ml	UK	13305001	08/2013	07/2016	No
AMX3	125 mg/5 ml	Ghana	AS159	06/2015	04/2018	Yes
AMX4	125 mg/5 ml	Ghana	0270435	05/2015	04/2017	Yes
AMX5	125 mg/5 ml	Ghana	15009	05/2015	05/2018	Yes
AMX6	125 mg/5 ml	Ghana	2305P	05/2014	05/2016	No
Flucloxacillin
FCX1	125 mg/5 ml	India	150079	01/2015	12/2017	No
FCX2	125 mg/5 ml	Ghana	2307R	07/2015	07/2017	Yes
FCX3	125 mg/5 ml	Ghana	0390315	09/2015	08/2017	Yes
FCX4	125 mg/5 ml	Ghana	15021	08/2015	08/2018	No
Cefuroxime
CFX1	125 mg/5 ml	Ghana	4808R	08/2015	08/2017	No
CFX2	125 mg/5 ml	India	BS-59001	07/2015	06/2017	Yes
CFX3	125 mg/5 ml	UK	C703319	10/2014	10/2016	No
CFX4	125 mg/5 ml	India	83	08/2015	07/2017	No
CFX5	125 mg/5 ml	UK	STR44A00	08/2014	08/2016	Yes
CFX6	125 mg/5 m	India	CFL-073	10/2015	10/2017	Yes
Artemether-lumefantrine
ATL1	20 mg/120 mg/5 ml	India	0633	02/2014	02/2016	Yes
ATL2	20 mg/120 mg/5 ml	Ghana	LG-414	02/2015	01/2017	Yes
ATL3	20 mg/120 mg/5 ml	Ghana	2804R	03/2016	03/2018	No
ATL4	20 mg/120 mg/5 ml	India	3A09150	01/2015	12/2017	Yes
Mebendazole
MBZ1	100 mg/5 ml	Belgium	DLB 3600	01/2014	12/2018	No
MBZ2	100 mg/5 ml	Ghana	15001	05/2015	05/2018	No
MBZ3	100 mg/5 ml	Ghana	0780165	07/2015	06/2017	No
MBZ4	100 mg/5 ml	Ghana	12	03/2015	03/2018	Yes
MBZ5	100 mg/5 ml	Ghana	M2002	09/2014	08/2017	No
Albendazole
ABZ1	100 mg/5 ml	India	340960	08/2014	07/2017	No
ABZ2	200 mg/5 ml	India	G4016	06/2014	05/2017	Yes
ABZ3	100 mg/5 ml	India	W150828	08/2015	07/2018	Yes
ABZ4	100 mg/5 ml	India	14328	05/2014	04/2017	Yes
ABZ5	100 mg/5 ml	India	340953	08/2014	07/2017	Yes
ABZ6	100 mg/5 ml	India	T140023	03/2014	02/2017	No
ABZ7	100 mg/5 ml	India	L-564001	02/2014	01/2017	Yes
ABZ8	200 mg/5 ml	India	331134	11/2013	10/2016	No
Griseofulvin
GFV1	125 mg/5 ml	India	GS 1401	01/2014	02/2016	Yes
GFV2	125 mg/5 ml	India	5E 01045	02/2015	01/2018	Yes
GFV3	125 mg/5 ml	Ghana	001	05/2015	05/2018	No
Ferrous sulphate
FES1	10 mg/5 ml	Ghana	VL 785	10/2015	09/2017	Yes
FES2	75 mg/5 ml	India	2F140KE	12/2014	11/2016	No
FES3	200 mg/5 ml	India	T140011	07/2014	07/2016	No
Multivitamin
MVM1	2 mg/5 ml (Vit B1, B2), 2 mcg/5 ml (Vit B3), 0.225 mg/5 ml (Vit B6)	Ghana	AY 231	06/2015	05/2017	Yes
MVM2	2 mg/5 ml (Vit B1), 1.2 mg/5 ml (Vit B3), 0.2 mg/5 ml (Vit B6)	Ghana	0290158	02/2016	02/2017	Yes
Folic acid
FLA1	500 mcg/5 ml	Ghana	0430025	09/2015	11/2016	No
FLA2	500 mcg/5 ml	Ghana	FO-035	11/2014	10/2016	Yes
Paracetamol
PCM1	125 mg/5 ml	UK	AS 17120	02/2015	02/2018	No
PCM2	125 mg/5 ml	Ghana	RNA2P018	08/2015	08/2018	Yes
PCM3	125 mg/5 ml	Ghana	3609R	09/2015	09/2018	No
PCM4	125 mg/5 ml	Ghana	10L319	10/2013	09/2016	Yes
PCM5	125 mg/5 ml	Ghana	E 005	10/2015	09/2018	No
PCM6	125 mg/5 ml	Ghana	0361865	10/2015	09/2017	Yes
PCM7	125 mg/5 ml	Ghana	1008F	08/2015	08/2018	Yes
Ibuprofen
IBF1	100 mg/5 ml	UK	IBXT-002	09/2014	08/2017	No
IBF2	100 mg/5 ml	Ghana	1506P	06/2014	06/2017	No
IBF3	100 mg/5 ml	Ghana	E001	04/2015	04/2017	No
IBF4	100 mg/5 ml	India	IB4 001	09/2014	08/2017	No
IBF5	100 mg/5 ml	Ghana	1030025	09/2014	08/2017	Yes

(a) CPF = ciprofloxacin suspension, CTX = cotrimoxazole suspension, MTZ = metronidazole suspension, AMX = amoxicillin suspension, FCX = flucloxacillin suspension, CFX = cefuroxime suspension, ATL = Artemether-lumefantrine suspension, MBZ = mebendazole suspension, ABZ = albendazole suspension, GFV = griseofulvin suspension, FES = ferrous sulphate syrup, MVM = multivitamin syrup, FLA = folic acid suspension, PCM = paracetamol syrup, and IBF = ibuprofen suspension; (b) FDA = Food and Drugs Authority, Ghana; PML =p manufacturing license; (c) the numbers indicated against a particular product are different brands of the same drug.