Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort
Table 3
Effect of prenatal exposure to P. falciparum, gravidity, season of birth, parasite density, timing of malaria episodes, and birth weight on IL-10 and IFN-γ responses during clinical malaria episodes: Multiple linear regression model (MLRM).
Factor
Univariate analysis
Multivariate analysis
IL-10
Coefficient (95% CI)
P value
Coefficient (95% CI)
P value
IUE P. falciparum
0.17 (0.050-0.288)
0.006
9.176 (3.11-15.20)
0.004
Gravidity
0.04 (-0.086-0.157)
0.558
5.722 (-0.023-11.468)
0.063
Season of birth
-0.04 (0.201-0.118)
0.604
0.401 (-6.575-7.378)
0.909
Infant birth weight
-0.035 (-0.185-0.116)
0.649
2.315 (-4.422-9.052)
0.496
Parasite density
3.41 (0.616-6.209)
0.015
-4.689 (-16.687-7.31)
0.438
Timing to malaria episodes
-1.205 (-7.088-4.675)
0.684
-1.846 (-4.382-2.581)
0.739
IFN-
IUET P. falciparum
-0.056 (-0.096- -0.016)
0.007
-90.92 (151.697- -30.145
0.003
Gravidity
-0.006 (-0.046-0.035)
0.771
-38.832 (-96.415-18.750)
0.183
Season of birth
-0.042 (-0.094-0.010)
0.115
-74.873 (-144.79-4.956)
0.076
Infant birth weight
0.023 (-0.026-0.073)
0.035
13.822 (-53.69-81.34)
0.684
Parasite density
0.06 (-0.015-0.027)
0.587
77.522 (-42.726-197.77)
0.202
Timing to malaria episodes
-0.008 (-0.020-0.004)
0.197
-12.651 (-23.32-7.762)
0.235
IUE P. falciparum:in utero exposure to P. falciparum, SD: standard deviation, CI: confidence interval.
