Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds

Table 2

ED₅₀ of sarcosine-aniline hybrid versus control drugs on P. berghei ANKA.

	Drugs	ED50	value
			1	2	3	4	5	6
1	Sarcosine-aniline hybrid drug	6.49 mg/kg		p ^a	0.1	p ^a	p ^a	p ^a
2	Aniline	3.61 mg/kg	p ^a		p ^a	p ^a	p ^a	p ^a
3	Artesunate-aniline hybrid	3.56 mg/kg	p ^a	0.1		p ^a	p ^a	p ^a
4	Artesunate	2.94 mg/kg	p ^a	0.424	p ^a		p ^a	p ^a
5	Chloroquine	1.78 mg/kg	p ^a	p ^a	p ^a	p ^a		p ^a
6	Sarcosine	No activity	p ^a	p ^a	p ^a	p ^a	p ^a

p ^a: significant, .