Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Drugs</td><td class="align_center">Day 7</td><td class="align_center">Day 9</td><td class="align_center">Day 11</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Sarcosine-aniline hybrid</td><td class="align_center">9.74</td><td class="align_center">12.98</td><td class="align_center">15.61</td></tr><tr><td class="align_left">Aniline</td><td class="align_center">6.97</td><td class="align_center">9.03</td><td class="align_center">11.84</td></tr><tr><td class="align_left">Artesunate</td><td class="align_center">0.00</td><td class="align_center">0.2</td><td class="align_center">0.67</td></tr><tr><td class="align_left">CQ</td><td class="align_center">0.00</td><td class="align_center">0.03</td><td class="align_center">0.42</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Parasitaemia growth of sarcosine-aniline hybrid after stopping treatment.</div>

Journal of Tropical Medicine

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Table 3

Table 3: Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds 