Research Article
Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds
Table 4
Survival rate after 11 days of in vivo efficacy testing.
| | Dosage (mg/kg) | Sarcosine-aniline hybrid | Sarcosine | 3-Chloro-4-(4-chlorophenoxy) aniline | Artesunate | Artesunate-aniline hybrid | Chloroquine |
| | 10 | 3 | 1 | 4 | 5 | 3 | 5 | | 5 | 2 | 2 | 2 | 3 | 2 | 4 | | 2.5 | 1 | 1 | 3 | 4 | 3 | 4 | | 1.25 | 1 | 1 | 3 | 3 | 3 | 3 | | 0.625 | 1 | 0 | 1 | 2 | 1 | 3 |
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