LC-MS Analysis, 15-Lipoxygenase Inhibition, Cytotoxicity, and Genotoxicity of Dissotis multiflora (Sm) Triana (Melastomataceae) and Paullinia pinnata Linn (Sapindaceae)

Table 1

Cytotoxic effects and selectivity index values of ethanolic leaf extract of D. multiflora and P. pinnata on Vero cells.

Plant	LC50 (mg/mL)	Selectivity index (SI)
		S. typhi	S. flex	K. pneu	B. cer	E. coli	P. mirab
D. multiflora	1.00 ± 0.00	10.30	5.12	5.12	1.28	2.56	2.56
P. pinnata	0.13 ± 0.06	0.16	0.66	0.33	0.16	0.16	0.33
Doxorubicin	5.92 ± 1.21	—	—	—	—	—	—

S. typhi: Salmonella typhi; S. flex: Shigella flexneri; K. pneu: K. pneumoniae; B. cer: Bacillus cereus; E. coli: Escherichia coli; P. mirab: Proteus mirabilis. Doxorubicin hydrochloride in μg/mL was used as positive control. Minimum inhibitory concentration values of extracts (mg/mL) from previous works; LC₅₀ = Lowest concentration of extract which is lethal to 50% of the cells.