Antimalarial Activity of Aqueous and 80% Methanol Crude Seed Extracts and Solvent Fractions of Schinus molle Linnaeus (Anacardiaceae) in Plasmodium berghei-Infected Mice
Table 1
The effect of crude seed extracts and solvent fractions of S. molle on parasitemia and survival time of P. berghei-infected mice.
Group
% parasitemia
% suppression
Survival time (day)
80ME100
33.01 ± 0.92
35.72
9.50 ± 0.43
80ME200
22.75 ± 0.83
55.70
10.17 ± 0.48
80ME400
16.99 ± 0.73
66.91
13.83 ± 0.87
CON
51.35 ± 1.66
0.00
6.33 ± 0.49
CQ10
0.00 ± 0.00
100.00
>30.00 ± 0.00
AE100
38.00 ± 1.32
27.18
6.50 ± 0.34
AE200
35.42 ± 1.20
32.15
6.67 ± 0.33
AE400
33.89 ± 1.32
35.08
8.00 ± 0.37
CON
52.20 ± 2.20
0.00
6.33 ± 0.21
CQ10
0.00 ± 0.00
100.00
>30.00 ± 0.00
CF100
37.52 ± 1.10
32.69
8.33 ± 0.33
CF200
34.02 ± 0.93
38.97
9.17 ± 0.31
CF400
24.75 ± 1.37
55.60
12.17 ± 0.48
CON
55.74 ± 1.06
0.00
6.33 ± 0.42
CQ10
0.00 ± 0.00
100.00
>30.00 ± 0.00
BF100
36.23 ± 1.32
31.49
8.17 ± 0.40
BF200
33.00 ± 1.20
37.59
8.67 ± 0.49
BF400
29.28 ± 1.67
44.63
10.67 ± 0.67
CON
52.88 ± 2.20
0.00
6.17 ± 0.31
CQ10
0.00 ± 0.00
100.00
>30.00 ± 0.00
AF100
43.52 ± 0.92
15.64
6.50 ± 0.43
AF200
41.51 ± 1.33
19.54
6.83 ± 0.48
AF400
38.05 ± 1.59
26.25
7.33 ± 0.49
CON
51.59 ± 1.64
0.00
6.33 ± 0.33
CQ10
0.00 ± 0.00
100.00
>30.00 ± 0.00
Data are expressed as mean ± SEM (n = 6); acompared to either CON; bcompared to 100 mg/kg; ccompared to 200 mg/kg; dcompared to 400 mg/kg; ecompared to CQ10; and . AE = aqueous crude extract, 80ME = 80% methanol crude extract, CF = chloroform fraction, BF = butanol fraction, AF = aqueous fraction, CON = control, and CQ = chloroquine base. Numbers after letters in the first column refer to dose in mg/kg.
