Successful Outpatient Management of Children at a Secondary Care Hospital in Pakistan in a Dengue Fever Epidemic and Their Clinical Outcomes
Table 4
Comparison of baseline characteristics of patients with dengue fever who remained stable with the patients who had deterioration of disease on follow-up.
Dengue fever (n = 81)
Deterioration of disease (n = 6)
value
Age (years) ± SD
7.65 ± 2.77
9.67 ± 2.50
0.087
Sex
Male, n (%)
34 (42)
5 (83.3)
0.049
Female, n (%)
47 (58)
1 (16.7)
Duration of illness in days (mean ± SD)
3 ± 0.95
2.67 ± 0.52
0.399
Vitals
Pulse (bpm) (mean ± SD)
105.3 ± 5.27
108 ± 5.8
0.232
Temperature (°F) (mean ± SD)
100.3 ± 0.73
100.8 ± 0.41
0.096
Hypotension
0
0
—
Fast breathing
3 (6.2%)
2 (33.3%)
0.009
Clinical features
Fever, aches, pain, burning eyes, n (%)
81 (100)
6 (100)
—
Vomiting, n (%)
33 (40.7)
3 (50)
0.657
Headache, n (%)
34 (42)
2 (33.3)
0.678
Cough, n (%)
6 (7.4)
1 (16.7)
0.421
Diarrhea, n (%)
5 (6.2)
0
0.531
Rash, n (%)
5 (6.2)
0
0.531
Abdominal pain, n (%)
1 (1.2)
0
0.784
Muscle soreness, n (%)
4 (4.9)
0
0.577
Petechiae, n (%)
0
10
Investigations
Hemoglobin (g/dl) (mean ± SD)
11.04 ± 1.08
11.02 ± 1.08
0.952
Total leucocyte count (x103/μl) (mean ± SD)
5280.2 ± 1247.7
4633.3 ± 422.7
0.212
Range of total leucocyte count (×103/μl)
2800–9500
2700–5400
Number of patients with total leucocyte count <4000 (×103/μl)
20 (24.7%)
6 (100%)
—
Total platelet count (×103/μl) (mean ± SD)
198.7 ± 43.4
156.8 ± 108.7
0.022
Range of platelets (×103/μl)
73–316
16–178
Number of patients with platelet count <150000 (×103/μl)
18 (22%)
6 (100%)
Number of patients with platelet count <50,000 (×103/μl)
0
5 (83.3%)
Hematocrit (%) (mean ± SD)
36.3 ± 1.7
38.7 ± 1.3
0.001
Range of hematocrit (%)
33–41.5
38–46
Hematocrit maximum (%) (mean ± SD)
37.6 ± 1.9
40.6 ± 2.9
0.001
Hematocrit minimum (%) (mean ± SD)
36.3 ± 1.7
38.7 ± 1.3
0.001
6% Hemoconcentration change (mean ± SD)
3.7 ± 1.8
4.9 ± 4.9
0.179
PT deranged mild
0
5 (83.3%)
APTT
0
4 (66.7%)
USG abdomen
0
20
—
CXR
0
30
—
4Raised ALT
2 (3.0%)
72 (33.3%)
—
5Raised AST
2 (3.0%)
72 (33.3%)
—
1Two patients later on developed petechiae. 2Later USG showed ascites in one and gall bladder wall odema in other patient. 3Later 1 patient showed pleural effusion. 4ALT was done in 72 patients in total (66 in DF and 6 in those who deteriorated). 5AST was done in 67 patients (61 in DF and 6 in those who deteriorated). Both groups had mildly raised ALT and AST at initial presentation. 6%Hemoconcentration change (HCT maximum–HCT minimum/HCT min x100). 7Two patients, one with previously normal liver enzymes and one with previously mildly raised enzymes, developed markedly raised enzymes later on.
