In Vivo Antimalarial Activity of Leaf Latex of Aloe melanacantha against Plasmodium berghei Infected Mice

Table 3

Effect of A. melanacantha leaf latex on body weight of Plasmodium berghei infected mice.

Test substance	Doses (mg/kg)	D0	D4	Weight change
Distilled water	10 ml/kg	40.32 ± 2.3	35.4 ± 3.1	−4.92
A. melanacantha	100 mg/kg	33.38 ± 0.9	31 ± 2.7	−2.38^a
Leaf latex	200 mg/kg	34.18 ± 2.28	32.1 ± 2.87	−2.08^a
	400 mg/kg	41.1 ± 0.92	36.8 ± 2.65	−4.3
Chloroquine	10 mg/kg	40.3 ± 2.3	41.6 ± 2.2	1.3^b

Data are expressed as mean ± standard deviation (n = 5) where a = significant compared to the control group, b = significant compared to control group (CQ), D0 = day 0, and D4 = day 4.