In Vivo Antimalarial Activity of Leaf Latex of Aloe melanacantha against Plasmodium berghei Infected Mice

Table 5

Effect of Aloe melanacantha leaf latex on packed cell volume of Plasmodium berghei infected mice.

Test substance	Doses (mg/kg)	D0	D4	PCV change
Distilled water	10 ml/kg	60.8 ± 0.04	60.4 ± 0.04	−0.4
A. melanacantha	100 mg/kg	56.8 ± 0.08	56.2 ± 0.85	−0.6
Leaf latex	200 mg/kg	55 ± 0.06	55.4 ± 0.71	0.4^a
	400 mg/kg	54.2 ± 0.055	54.4 ± 0.08	0.2^a
Chloroquine	10 mg/kg	59.8 ± 0.02	60.4 ± 0.02	0.6^b

Values are expressed as mean ± standard deviation (n = 5), a = significant compared to the control group, b = significant compared to control group (CQ), D0 = day 0, and D4 = day 4.