Research Article
In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives
Table 1
The percentage of Plasmodium growth inhibition of hydroxyxanthone derivatives and chloroquine on P. falciparum 3D-7 and FCR-3.
| Compound | Concentration (μM) | Growth inhibition of P. falciparum (%) | Strain 3D-7 | Strain FCR-3 |
| 1,6,8-Trihydroxyxanthone (HX1) | 102.38 | 75.864 ± 0.471 | 73.671 ± 4.277 | 51.19 | 69.033 ± 0.888 | 64.446 ± 0.671 | 25.59 | 64.726 ± 0.861 | 60.171 ± 2.739 | 12.8 | 61.479 ± 0.710 | 55.160 ± 3.588 | 6.39 | 47.405 ± 5.857 | 50.894 ± 2.308 |
| 1,6-Dihidroxyxanthone (HX2) | 876.42 | 90.560 ± 0.665 | 87.623 ± 2.239 | 438.21 | 73.618 ± 0.713 | 74.226 ± 1.318 | 219.11 | 67.164 ± 0.601 | 67.144 ± 2.757 | 109.55 | 54.805 ± 2.433 | 50.248 ± 2.629 | 54.78 | 49.172 ± 1.606 | 47.192 ± 0.687 |
| 1,5,6-Trihydroxyxanthone (HX3) | 409.5 | 87.438 ± 1.154 | 82.978 ± 1.396 | 204.75 | 80.923 ± 0.679 | 71.858 ± 7.842 | 102.38 | 68.886 ± 0.151 | 51.920 ± 0.466 | 51.19 | 63.400 ± 0.421 | 43.133 ± 0.126 | 25.59 | 47.295 ± 0.611 | 38.265 ± 1.186 |
| 1-Hydroxy-5-chloroxanthone (HX4) | 810.86 | 74.002 ± 0.923 | 72.933 ± 1.345 | 405.43 | 64.513 ± 0.418 | 61.202 ± 3.024 | 202.71 | 57.136 ± 1.574 | 56.371 ± 3.792 | 101.36 | 50.963 ± 0.361 | 49.754 ± 3.361 | 50.68 | 46.473 ± 0.800 | 47.388 ± 0.736 |
| 1,6-Dihydroxy-5-methylxanthone (HX5) | 330.25 | 93.288 ± 0.956 | 84.664 ± 0.902 | 165.13 | 75.364 ± 1.287 | 73.462 ± 1.596 | 82.56 | 54.180 ± 1.574 | 46.519 ± 0.816 | 41.28 | 45.041 ± 0.563 | 41.140 ± 0.396 | 20.64 | 37.886 ± 0.441 | 33.632 ± 0.327 |
| Chloroquine | 0.037 | 97.766 ± 0.690 | 84.189 ± 2.449 | 0.029 | 97.490 ± 0.517 | 82.599 ± 2.945 | 0.023 | 96.581 ± 1.330 | 79.923 ± 3.863 | 0.016 | 96.354 ± 1.131 | 78.570 ± 4.507 | 0.008 | 54.415 ± 12.42 | 18.748 ± 9.233 |
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