In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives

Table 2

The IC₅₀ values of hydroxyxanthone derivatives on Plasmodium falciparum 3D-7 and FCR-3 after 72 hours incubation period using microscopic method.

Compound	Structure	IC50 (μM) on P. falciparum 3D-7	IC50 (μM) on P. falciparum FCR-3
1,6,8-Trihydroxyxanthone (HX1)		6.10 ± 2.01	6.76 ± 2.38
1,6-Dihydroxyxanthone (HX2)		71.78 ± 0.31	81.77 ± 5.78
1,5,6-Trihydroxyxanthone (HX3)		27.64 ± 0.19	64.09 ± 5.08
1-Hydroxy-5-chloroxanthone (HX4)		85,30 ± 0.87	89.85 ± 7.69
1,6-Dihydroxy-5-methylxanthone (HX5)		46.69 ± 0.29	59.73 ± 0.78
Chloroquine		0.01 ± 0.001	0.11 ± 0.052