In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives

Table 3

The IC₅₀ value of 1,6,8-trihydroxyxanthone (HX1) compound and chloroquine on the formation of the β-hematin using method of HPIA.

Compounds	Concentration (mM)	β-Hematin (mM)	Inhibition of β-hematin (%)	IC50 (mM)
HX1	20.475	9.684	91.171	2.854
	10.238	14.376	86.893
	5.119	54.448	50.359
	2.580	55.776	49.149
	1.269	72.500	33.901
Chloroquine	9.692	12.500	88.604	1.478
	4.846	22.040	79.906
	2.423	47.845	56.379
	1.221	57.787	47.315
	0.601	77.787	29.080