In Vitro Antiplasmodial, Heme Polymerization, and Cytotoxicity of Hydroxyxanthone Derivatives

Table 5

The selectivity index (ratio IC₅₀ on Vero cell/IC₅₀ on plasmodium) of hydroxyxanthone compounds and chloroquine.

Compounds	IC50 on Vero cell (μM)	Selectivity index
		3D-7	FCR-3
HX1	3394.90	556.54	502.20
HX2	308.32	4.30	3.77
HX3	224.45	8.12	3.50
HX4	330.68	3.88	3.68
HX5	417.57	8.94	6.99
Chloroquine	2216.92	221692	20153.82