Review Article
The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review
Table 2
Several studies related to piperine as an antiplasmodium.
| No | Activities | Subject | Type of study | Findings/Outcome | Reference |
| 1 | Antioxidant activity | P. falciparum of FCK2 and INDO strains | In vitro | Piper nigrum exhibited antiplasmodial activity at IC50 <50 μg/mL in P. falciparum lactate dehydrogenase (PfLDH) inhibition assay | [10] | 2 | Chloroquine (CQ) sensitive 3D7 and CQ-resistant INDO strains of P. falciparum | In vitro | Piper nigrum IC50:12.5 μg/mL showed antiplasmodial activity | [38] | 3 | K1 (chloroquine-resistant) P. falciparum and 3D7 (chloroquine-sensitive) | In vitro | Piperine IC50: 111.5 and 59 μM changes parasite morphology after 48 hours of exposure and has a low risk of resistance | [40] | 4 | K1 (chloroquine-resistant) P. falciparum and 3D7 (chloroquine-sensitive) | In vitro | The extract piper chaba hunt showed potent antimalarial activity IC50: <10 μg/ml | [88] |
| 5 | Chemoprophylaxis | Human | Survey | Piper nigrum were used in decoction form for malaria chemoprophylaxis | [33] |
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