The Potential use of a Curcumin-Piperine Combination as an Antimalarial Agent: A Systematic Review

Table 2

Several studies related to piperine as an antiplasmodium.

No	Activities	Subject	Type of study	Findings/Outcome	Reference
1	Antioxidant activity	P. falciparum of FCK2 and INDO strains	In vitro	Piper nigrum exhibited antiplasmodial activity at IC50 <50 μg/mL in P. falciparum lactate dehydrogenase (PfLDH) inhibition assay	[10]
2		Chloroquine (CQ) sensitive 3D7 and CQ-resistant INDO strains of P. falciparum	In vitro	Piper nigrum IC50:12.5 μg/mL showed antiplasmodial activity	[38]
3		K1 (chloroquine-resistant) P. falciparum and 3D7 (chloroquine-sensitive)	In vitro	Piperine IC50: 111.5 and 59 μM changes parasite morphology after 48 hours of exposure and has a low risk of resistance	[40]
4		K1 (chloroquine-resistant) P. falciparum and 3D7 (chloroquine-sensitive)	In vitro	The extract piper chaba hunt showed potent antimalarial activity IC50: <10 μg/ml	[88]
5	Chemoprophylaxis	Human	Survey	Piper nigrum were used in decoction form for malaria chemoprophylaxis	[33]