Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade

Table 2

The anticancer effects of 1′-acetoxychavicol acetate on different cell lines.

Cancer type	Cell line	Effects	Reference
Breast	MCF-7	Cytotoxicity	[70]
		Activation of caspase-3, apoptosis	[71]
		Inactivation of NF-ĸB pathway and downregulation of its genes	[72]
	MDA-MB-231	Cytotoxicity	[73]
		Activation of caspase-3	[71]
	4T1	Downregulation of MMP-9 and VEGF, upregulation of IL-2 and IL-10, antitumour	[74]
Cervical	CaSki	Upregulation of has-miR-138, has-miR-210, and has-miR-744	[75]
	CaSki and SiHa	Overexpression of RSU1, antiproliferation, apoptosis	[76]
		Downregulation of miR-210, upregulation of SMAD4	[77]
Colon	SW-480	Cell cycle arrest, upregulation of p21, reduction of cyclin D, antiproliferation	[78]
	Colo 320	Antiproliferation, apoptosis	[79]
Lung	A549	Inactivation of NF-ĸB pathway and downregulation of its genes, cytotoxicity, antitumour	[80]
		Induced prosurvival autophagy through Beclin-1-independent pathway	[81]
Prostate	PC-3	Inactivation of NF-ĸB pathway and downregulation of its genes, cytotoxicity, antitumour	[62]
		Downregulation of CXCR4, VEGF, p65, and Ki-67, antitumour	[74]
		Antiproliferation, antimigration, antiadhesion, downregulation of Src, CD31, VEGF	[82]
Oral	HSC-4	Apoptosis, antimigration, antitumour, downregulation FasL, Bim, NF-κB, COX-2 and cyclin D1	[83]