Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade

Table 3

The anticancer effects of genistein on different cell lines.

Cancer type	Cell line	Effects	Reference
Adenoid cystic	ACC	Inhibition of MMP-9, antimetastatic	[89]
Bladder	RT4, J82, 5637, T24	Downregulation of VEGF, upregulation PAL-1, endostatin, angiostatin, and THBS-1	[90]
Breast	MDA-MB-231	Activation of ERK1/2 pathway, induction of cell cycle arrest at the G2/M phase, downregulation of Cdk1, cyclin B1, and Cdc25 C	[91]
Cervical	HeLa	Activation of caspase-9 and -3	[92]
Colon	HT-29	Inhibition of NF-ĸB	[93]
		Activation of caspase-3 and p38/MAPK	[94]
	HCT-116	Anti-roliferation, cell cycle arrest at the G2/M phase	(Mizushina et al., 2013)
		Inhibition of MMP-9, COX-2, Ang-1, VASP, VEGF, anti-etastatic	[95]
	SW-480	Cell cycle arrest at the G2/M phase, apoptosis via ATM/p53 pathway	[53]
Gastric	HGC-27	Induction of cell cycle arrest at the G2/M phase	[96]
Lung	A549	Reduction of ERK1/2, PI3K/Akt and MMP-2	[97]
Melanoma	B16F10	Downregulation of Snail	[98]
Oral squamous	HSC-3	Downregulation of VEGF, anti-invasion	[99]
Thyroid	CAL-62, ACC 448, CGTH-W1, ACC 360	Cytotoxicity, downregulation of VEGF, hTERT, NF-ĸB genes, upregulation of PTEN and p21 mRNA	[100]